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Smoking: Effects, Risks, Diseases, Quitting & Solutions Is Nicotine a Stimulant or Depressant? Harmony Ridge Recovery Center WV Menthol facilitates dopamine releasing effect of nicotine in rat nucleus accumbens ScienceDirect Nicotine addiction can become a cycle of dopamine release, withdrawal, and cravings that reinforces continued nicotine use. The tobacco industry profits from keeping this cycle going. What feels like relief is often
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